an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.

hyaluronic acid (/?ha?.?lj???r?n?k/; abbreviated ha; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. it is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the golgi apparatus, and can be very large: human synovial ha averages about 7 million da per molecule, or about 20,000 disaccharide monomers, while other sources mention 3–4 million da.

as one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and also[vague] may be involved in the progression of some m

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